Knowledge Centre
PregnancyDraft: awaiting clinical review
Recurrent miscarriage
Experiencing two or more pregnancy losses, and the investigations and support available.
Overview
Losing a pregnancy is distressing, and experiencing more than one loss can be especially hard. You are not alone, and support is available.
Current UK guidance from the Royal College of Obstetricians and Gynaecologists (2023) recommends investigations after two or more first-trimester losses.
What is well established
- Recommended investigations include testing for antiphospholipid antibodies, checking thyroid function, genetic testing of pregnancy tissue where possible, and a pelvic ultrasound to assess the shape of the womb.
- Antiphospholipid syndrome is a treatable cause.
- Many couples have no cause identified, and most still go on to have a successful pregnancy.
- Supportive care in an early pregnancy clinic is valued by many people.
Uncertain or emerging evidence
- Immune treatments and natural killer (NK) cell testing are not recommended outside research, as evidence of benefit is lacking.
When to seek help
If you are pregnant and have heavy bleeding, severe pain, or feel faint, call 999 or go to A&E.
This guide is general information and does not replace advice about your own circumstances. Clinical review pending.